Methotrexate toxicity treated with continuous venovenous hemofiltration, leucovorin and glucarpidase
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Methotrexate toxicity treated with continuous venovenous hemofiltration, leucovorin and glucarpidase
High-dose methotrexate (MTX) can produce acute kidney injury, impairing MTX elimination. Continuous venovenous hemofiltration (CVVH) may enhance elimination in this setting, although its use is largely unstudied. A 79-year-old man received IV MTX for central nervous system lymphoma, and over a 34-h period his serum creatinine increased from 1.09 to 2.24 mg/dL. His serum MTX concentration (sMTX)...
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Methotrexate (MTX) is used to treat various disorders and can be safely administered at high doses if renal function is adequate, high urine output (UOP) is maintained, urine is alkalinized and leucovorin rescue is given. Despite those measures, toxicity (mucositis, diarrhea, renal dysfunction and myelosuppression) occurs with prolonged high serum drug concentrations [1]. Dialysis-based methods...
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ژورنال
عنوان ژورنال: Clinical Kidney Journal
سال: 2014
ISSN: 2048-8505,2048-8513
DOI: 10.1093/ckj/sfu093